A UNIQUE ADIPOCYTE PROGENITOR POPULATION PROMOTES AGE-RELATED ADIPOSITY

Abstract The average fat mass in adults increases dramatically with age, and older people often suffer from visceral obesity related adverse metabolic disorders. Unfortunately, how aging leads to accumulation is poorly understood. It known that cell (adipocyte) turnover very low young mice, similar humans. Here, we find mice mimic age-related expansion In vivo lineage tracing shows massive adipogenesis (the generation of new adipocytes), especially the fat, triggered during aging. Thus, contrast most types adult stem cells exhibit a reduced ability proliferate differentiate, adipogenic potential adipocyte progenitor (APCs) unlocked by transplantation 3D imaging transplants show APCs aged cell-autonomously gain high capacity. Single-cell RNA sequencing analyses reveal globally remodels APCs. Herein, identify novel committed preadipocyte population age-specific (CP-A), existing both humans, global activation proliferation pathways. CP-A display activity, vitro. LIFR serves as functional maker CP-A, which promotes proliferation. Together, these findings define fundamental mechanism involved tissue offer prospects for preventing treating